报告题目：The mechanics of dementia/ 大脑痴呆力学
报告人：Alain Gireily院士 牛津大学
报告时间：2024年08月25日上午9:30
报告地点：明故宫校区A8号楼7层报告厅
主办单位：国际合作处、航空学院、航空航天结构力学及控制全国重点实验室、多功能轻量化材料与结构工信部重点实验
报告内容简介：
Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are devastating conditions with poorly understood mechanisms and no known cure. Yet a striking feature of these conditions is the characteristic pattern of invasion throughout the brain, leading to well-codified disease stages visible to neuropathology and associated with cognitive deficits and atrophy. This evolution is associated with the aggregation of key toxic proteins. In this talk, I will show how we use mechanistic modelling to gain insight into this process In particular, by looking at protein dynamics on the neuronal network, we can unravel some of the universal features associated with dementia that are driven by both the network topology and protein kinetics and lead to brain atrophy.
报告人简介：
Alain Goriely担任英国皇家学会院士，牛津大学数学研究所教授，国际脑力学与创伤实验室（IBMTL）主任，牛津大学工业与应用数学中心（OCIAM）主任。1990年于布鲁塞尔自由大学获得博士学位。Alain Goriely院士获得了国际工程科学学会工程科学奖章（SES2024），以表彰他在脑组织生长力学和非线性非弹性领域的开创性贡献，这些贡献应用于工程、生物学、生理学、物理学和材料科学等多个领域。发表论文380余篇，出版著作3本，总计被引用19900余次，h因子65。曾获得斯坦福大学Timoshenko教授奖学金和艾萨克牛顿研究所杰出罗斯柴尔德访问基金。
Prof. Alain Goriely is the statutory Professor of Mathematical Modelling at the University of Oxford where he is also the Director of the Oxford Centre for Industrial and Applied Mathematics and a member of Saint Catherine’s College. He is a mathematician with broad interests in mathematical methods, mechanics, sciences, and engineering having authored more than 300 scientific papers and three books. He is well known for his contributions to dynamical systems, mathematical biology, as well as fundamental and applied mechanics. In addition, Alain enjoys scientific outreach based on problems connected to his research, including brain modelling, the mechanics of plants, the shape of seashells, twining plants, umbilical cord and whip cracking. His work has been recognized by a Sloan Fellowship, a Royal Society Wolfson Research Award, and the Cozzarelli Prize from the National Academy of Sciences. He was elected Fellow of the Royal Society in 2022 and Gresham Professor of Geometry at the Gresham College in 2024.
